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Chemical Structure : HSD992
Catalog No.: PC-63305Not For Human Use, Lab Use Only.
HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.
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HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.
HSD992 only poorly inhibits the activities of CDKs 1, 4, 5, 6, 14, 16, 17, 18 and 19, and does not inhibit PLK isoforms.
HSD992 inhibits HLY-1 and NCI-H520 with IC50 values of 232 nM and 307 nM, respectively, The IC50 values against other cell lines (LC-2/Ad, K562, HeLa, NCI-H1703 and DMS114) ranged from 427 nM to 723 nM.
| M.Wt | 370.474 | |
| Formula | C22H18N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Opoku-Temeng C, et al. Chem Commun (Camb). 2018 Apr 9. doi: 10.1039/c8cc01154k.
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