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HSK0935

Chemical Structure : HSK0935

CAS No.: 1638851-44-1

HSK0935 (HSK-0935;HSK 0935)

Catalog No.: PC-61130Not For Human Use, Lab Use Only.

A potent and highly selective SGLT2 inhibitor with IC50 of 1.3 nM, >800-fold selectivity over SGLT1 (IC50>1 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and highly selective SGLT2 inhibitor with IC50 of 1.3 nM, >800-fold selectivity over SGLT1 (IC50>1 uM); shows robust urinary glucose excretion in Sprague-Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys.

Physicochemical Properties

M.Wt 436.885
Formula C22H25ClO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,2S,3R,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-methoxy-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

References

1. Li Y, et al. J Med Chem. 2017 May 25;60(10):4173-4184.

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