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Chemical Structure : HSK205
Catalog No.: PC-22196Not For Human Use, Lab Use Only.
HSK205 is potent, dual FLT3/haspin kinase inhibitor, inhibits haspin and FLT3 at 97% and 94% at 50 nM respectively.
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HSK205 is potent, dual FLT3/haspin kinase inhibitor, inhibits haspin and FLT3 at 97% and 94% at 50 nM respectively.
HSK205 inhibits the FLT3-ITD and FLT3 D835Y enzyme with IC50 of 0.199 nM and 0.187 nM.
HSK205 could bind to haspin with Kd = 0.55 nM.
HSK205 has remarkable potencies against FLT3-driven AML cell lines, inhibiting proliferation with GI50 values between 2–25 nM.
HSK205 inhibits the phosphorylation of both FLT3 and histone H3 (a haspin target) in cells.
| M.Wt | 436.52 | |
| Formula | C26H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Allison L Kempen, et al. RSC Med Chem. 2023 Jul 14;14(9):1743-1754.
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