HST-1011 | Cbl-b inhibitor | Probechem Biochemicals

Chemical Structure : HST-1011

HST-1011 (HST1011)

Catalog No.: PC-25778Not For Human Use, Lab Use Only.

HST-1011 is a potent, selective, orally bioavailable allosteric small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), robustly increases anti-tumor immunity in vitro and in vivo.

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Biological Activity

Physicochemical Properties

M.Wt	538.62
Formula	C29H33F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((R)-cyclobutyl(4-methyl-4H-1,2,4-triazol-3-yl)methyl)phenyl)-6-(((S)-3-methylpiperidin-1-yl)methyl)-8-(trifluoromethyl)imidazo[1,5-a]pyridin-3(2H)-one

References

1. Jason Luke, et al. Cancer Res (2023) 83 (8_Supplement): CT251.

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HST-1011 (HST1011)

Biological Activity

Physicochemical Properties

References

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