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HT-0411

Chemical Structure : HT-0411

CAS No.: 947539-81-3

HT-0411 (HT0411)

Catalog No.: PC-61488Not For Human Use, Lab Use Only.

A selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2; causes CREB activation in vitro, improves 24-hour memory in rodents in a contextual fear conditioning model.

Physicochemical Properties

M.Wt 303.303
Formula C12H12F3N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-dimethyl-5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

References

1. Kaplan A, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758.

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