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Chemical Structure : HWG-35D
Catalog No.: PC-49708Not For Human Use, Lab Use Only.
HWG-35D is a potent, selective sphingosine kinase 2 (SphK2, SK2) with IC50 of 41 nM, 100-fold selectivity for SK2 over SK1.
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HWG-35D is a potent, selective sphingosine kinase 2 (SphK2, SK2) with IC50 of 41 nM, 100-fold selectivity for SK2 over SK1.
HWG-35D (0-500 nM) did not alter either SK1 or dihydroceramide desaturase 1 (DES1) protein expression in either human or murine cells, HWG-35D (300 nM) did not decrease SK1 protein levels in total CD4+ T cells isolated from mouse spleen.
HWG-35D topical application reduced psoriasis-like skin symptoms induced by imiquimod (IMQ), normalized the serum interleukin-17A levels elevated by IMQ.
HWG-35D also decreased skin mRNA levels of interleukin-17A, K6 and K16 genes induced by IMQ, blocked T helper type 17 differentiation of naïve CD4+ T cells with concomitant reduction of SOCS1.
HWG-35D dose-dependently increased Smad7 expression and ameliorated the expression of Col1, FN-1 and CTGF in primary renal fibroblasts.
HWG-35D demonstrated anti-fibrotic potential in unilateral ureter obstruction (UUO), a model for progressive renal fibrosis.
| M.Wt | 437.96 | |
| Formula | C26H28ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Adams D.R., et al. J Med. Chem. 2019;62:3658–3676.
2. Shin SH, et al. Cell Signal. 2021 Mar;79:109881.
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