Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HYOU1 inhibitor 33
Catalog No.: PC-21758Not For Human Use, Lab Use Only.
HYOU1 inhibitor 33 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 2.57 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HYOU1 inhibitor 33 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 2.57 uM.
HYOU1 inhibitor 33 downregulates the expression of Mmp3 and Bmp2 genes, both being highly upregulated in activated fibroblasts promoting chronic inflammation and fibrosis.
HYOU1 inhibitor 33 inhibits multiple pathways found activated in pathogenic fibroblasts, including extracellular matrisome alteration, TNFsignaling, cytokine/chemokine production and collagen fibril organization.
| M.Wt | 436.38 | |
| Formula | C22H27Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Papadopoulou D, et al. Angew Chem Int Ed Engl. 2024 Feb 10:e202319157.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
