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Chemical Structure : HZ-166
Catalog No.: PC-35484Not For Human Use, Lab Use Only.
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.
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HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.
HZ-166 displays a statistically significant higher affinity for receptors not containing the α1 subunit with a rank order of α5 (Ki=140nM) > α2 (Ki=269 nM) > α1 (Ki=382 nM).
The Ki value of HZ166 for the α3β3γ2 combination (185± 47 nM) was statistically significantly lower than the Ki value observed for α1β3γ2 but not different from those of α2β3γ2 and α5β3γ2.
HZ-166 is antihyperalgesic in mouse models of inflammatory and neuropathic pain.
| M.Wt | 356.385 | |
| Formula | C21H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fischer BD, et al. Neuropharmacology. 2010 Dec;59(7-8):612-8.
2. Di Lio A, et al. Neuropharmacology. 2011 Mar;60(4):626-32.
3. Witkin JM, et al. Neuropharmacology. 2018 Jul 15;137:332-343.
4. Rivas FM, et al. J Med Chem. 2009 Apr 9;52(7):1795-8.
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