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Hemin

Chemical Structure : Hemin

CAS No.: 16009-13-5

Hemin (Hemin chloride)

Catalog No.: PC-45633Not For Human Use, Lab Use Only.

Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type.

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Biological Activity

Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type.
Hemin increases the size of autophagic vacuoles and induces mitophagy in K562 cells; a heme oxygenase (HO)‑1 inducer.

Physicochemical Properties

M.Wt 651.9403
Formula C34H32ClFeN4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.6 mg/mL

Chemical Name/SMILES

Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-

References

1. Fader CM, et al. Biol Cell. 2016 Apr;108(4):77-95.

2. Higdon AN, et al. Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409.

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