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Chemical Structure : Hesperadin
CAS No.: 422513-13-1
Catalog No.: PC-42868Not For Human Use, Lab Use Only.
Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes.
Hesperadin inhibits histone H3 phosphorylation and causes midspindle defects, but does not inhibit APC and separase activation.
Hesperadin also markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK in vitro.
| M.Wt | 516.6544 | |
| Formula | C29H32N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethanesulfonamide, N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]- |
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1. Hauf S, et al. J Cell Biol. 2003 Apr 28;161(2):281-94.
2. Sessa F, et al. Mol Cell. 2005 Apr 29;18(3):379-91.
3. Kapoor TM, et al. Science. 2006 Jan 20;311(5759):388-91.
4. Jetton N, et al. Mol Microbiol. 2009 Apr;72(2):442-58.
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