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Chemical Structure : Hetrombopag
Catalog No.: PC-35778Not For Human Use, Lab Use Only.
Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.
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Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo.
Other Indication
Phase 2 Clinical
| M.Wt | 458.474 | |
| Formula | C25H22N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhou N, et al. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577.
2. Xie C, et al. J Cell Mol Med. 2018 Nov;22(11):5367-5377.
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