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Hsp90α inhibitor A17

Chemical Structure : Hsp90α inhibitor A17

CAS No.: 505057-98-7

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Hsp90α inhibitor A17 (Hsp90α/p23 inhibitor A17)

Catalog No.: PC-70363Not For Human Use, Lab Use Only.

Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1.
    A17 inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice.

    Physicochemical Properties

    M.Wt 384.333
    Formula C15H11F3N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide

    References

    1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.

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