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Chemical Structure : Hydrazinocurcumin
Catalog No.: PC-62432Not For Human Use, Lab Use Only.
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets.
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Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets.
Hydrazinocurcumin suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis.
Hydrazinocurcumin inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.
| M.Wt | 364.401 | |
| Formula | C21H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92.
2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44.
3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95.
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