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You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-c-Fms (CSF1R)-IACS-9439
IACS-9439

Chemical Structure : IACS-9439

CAS No.: 2231259-36-0

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IACS-9439 (IACS9439)

Catalog No.: PC-24734Not For Human Use, Lab Use Only.

IACS-9439 is a potent, highly selective, and orally bioavailable CSF1R inhibitor with IC50 of 1.7 nM, and cellular IC50 of 7 nM in the MNSF-60 cell phenotypical assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IACS-9439 is a potent, highly selective, and orally bioavailable CSF1R inhibitor with IC50 of 1.7 nM, and cellular IC50 of 7 nM in the MNSF-60 cell phenotypical assay.
IACS-9439 is high selective against a panel of kinases (ScanEdge, 97-member kinase panel, DiscoverX) at 1 uM.
IACS-9439 has IC50 of 17 in pCSF1R cellular target engagement assay.
IACS-9439 depletes tumor macrophages, promotes M1 macrophage, and inhibits tumor growth.

Physicochemical Properties

M.Wt 516.02
Formula C23H26ClN7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2S)-2-(7-Chloro-4-methoxy-6-((2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-yl)methoxy)benzo[d]thiazol-2-ylamino)cyclohexanol

References

1. Barbara Czako, et al. J Med Chem. 2020 Sep 10;63(17):9888-9911.

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