Chemical Structure : IB15C
CAS No.:
IB15C
Catalog No.: PC-27375Not For Human Use, Lab Use Only.
IB15C is a small molecule binder targeting the inhibitory immune receptor ILT3 (LILRB4, CD85k) with MST Kd of 0.92 uM, potently inhibits the ILT3-ApoE interaction with IC50 of 0.48 uM in ELISA-based competition assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IB15C is a small molecule binder targeting the inhibitory immune receptor ILT3 (LILRB4, CD85k) with MST Kd of 0.92 uM, potently inhibits the ILT3-ApoE interaction with IC50 of 0.48 uM in ELISA-based competition assays.
IB15C produces a robust concentration-dependent reduction in binding signal, with an IC50 of 0.64 uM in BLI assays.
IB15C disrupts ILT3-ApoE complex formation rather than indirectly altering assay components or protein stability.
IB15C (1-10 uM) reduced SHP1 and SHP2 phosphorylation in a concentration-dependent manner.
IB15C suppresses ILT3-dependent signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia.
IB15C attenuates NF-κB activation, significantly reduces IL-1β secretion and restores Aβ internalization.
Physicochemical Properties
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M.Wt
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383.45
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Formula
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C21H25N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(3,4-dimethoxyphenyl)propyl)-3-isopropylisoxazolo[5,4-b]pyridine-5-carboxamide
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References
1. Abdel-Rahman SA, et al. ACS Med Chem Lett. 2026 Jun 18;17(7):1647-1654.
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