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Chemical Structure : IBR2
CAS No.: 313526-24-8
Catalog No.: PC-62970Not For Human Use, Lab Use Only.
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
IBR2 disrupts RAD51 multimerization and inhibits RAD51-mediated HR repair, reduces RAD51 protein levels via proteasome-mediated degradation.
IBR2 inhibits cell growth and induces apoptosis in imatinib-resistant T315I-Ba/F3 cells。
IBR2 significantly prolongs animal survival in a murine imatinib-resistant CML model bearing the T315I Bcr-abl mutation.
| M.Wt | 400.496 | |
| Formula | C24H20N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline |
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1. Zhu J, et al. EMBO Mol Med. 2013 Mar;5(3):353-65.
2. Ferguson PJ, et al. J Pharmacol Exp Ther. 2017 Oct 23. pii: jpet.117.241661.
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