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Chemical Structure : IC-9564
Catalog No.: PC-62902Not For Human Use, Lab Use Only.
IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain.
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IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain.
IC-9564 also has IC90s of >5, 2.65, and 1.84 uM for DH012, QZ4734, and HIV-1 89.6, respectively.
HIV-1 gp120 plays a key role in the anti-HIV-1 activity of IC9564.
| M.Wt | 755.138 | |
| Formula | C46H78N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Holz-Smith SL, et al. Antimicrob Agents Chemother. 2001 Jan;45(1):60-6.
2. Narumi T, et al. Bioorg Med Chem. 2013 May 1;21(9):2518-26.
3. Sun IC, et al. J Med Chem. 2002 Sep 12;45(19):4271-5.
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