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Chemical Structure : IC261
CAS No.: 186611-52-9
Catalog No.: PC-43200Not For Human Use, Lab Use Only.
IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.
IC261 specifically blocks phosphorylation in vivo of the CK1delta/epsilon phosphorylation sites in p53 in murine SV3T3 cells, inhibits cytokinesis causing a transient mitotic arrest.
IC261 reduces pancreatic tumour cell growth in vitro and in vivo, decreases the expression levels of several anti-apoptotic proteins and sensitises cells to CD95-mediated apoptosis.
| M.Wt | 311.3319 | |
| Formula | C18H17NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
2H-Indol-2-one, 1,3-dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]- |
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1. Knippschild U, et al. Oncogene. 1997 Oct 2;15(14):1727-36.
2. Behrend L, et al. Oncogene. 2000 Nov 9;19(47):5303-13.
3. Mashhoon N, et al. J Biol Chem. 2000 Jun 30;275(26):20052-60.
4. Brockschmidt C, et al. Gut. 2008 Jun;57(6):799-806.
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