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Chemical Structure : ICeD-1
Catalog No.: PC-49298Not For Human Use, Lab Use Only.
ICeD-1 is a potent DPP9 inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
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ICeD-1 is a potent DPP9 inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
The efficacy of ICeD-1 is dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells.
ICeD-1 lowers the efficacious cell kill concentration of efavirenz to a clinically relevant dose at concentrations that do not result in complete DPP9 inhibition.
| M.Wt | 253.321 | |
| Formula | C13H20FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moore KP, et al. ACS Chem Biol. 2022 Aug 31. doi: 10.1021/acschembio.2c00515.
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