IDI-6273 |CAS:433945-73-4 Probechem Biochemicals

Chemical Structure : IDI-6273

IDI-6273 (IDI6273)

Catalog No.: PC-70339Not For Human Use, Lab Use Only.

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.

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Biological Activity

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
IDI-6273 displays 10.95-fold more active against 3D7 E182D than 3D7.
IDI-6273 does not yield resistant parasites with a combination of Genz-669178.

Physicochemical Properties

M.Wt	341.835
Formula	C20H20ClNO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one

References

1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.

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IDI-6273 (IDI6273)

Biological Activity

Physicochemical Properties

References

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