Chemical Structure : IGUANA-5
CAS No.:
IGUANA-5
(IGUANA 5)
Catalog No.: PC-28574Not For Human Use, Lab Use Only.
IGUANA-5 is a potent, selective next-generation ALDH1B1 inhibitor with biochemical IC50 of 13 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IGUANA-5 is a potent, selective next-generation ALDH1B1 inhibitor with biochemical IC50 of 13 nM.
IGUANA-5 inhibits LDH1A3−/−A375 cells overexpressing ALDH1B1 within 37% in ALDEFLUOR assays.
IGUANA-5 downregulates genes related to mitochondrial respiration (e.g. MT-CO3, MT-CO1, MT-ND5, MT-ND6) in Panc10.05 cells.
IGUANA-5 also significantly upregulates genes involved in cholesterol biosynthesis (e.g. HMGCS1, MSMO1, INSIG1, IDI1, MVD) in pancreatic cancer cells.
IGUANA-5 selectively blocks the growth of colon and pancreatic cancer spheroids and exhibits enhanced in vitro and in vivo pharmacological properties.
Physicochemical Properties
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M.Wt
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540.59
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Formula
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C29H31F3N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(3-(4-(Cyclohexyloxy)phenyl)-6,7-dihydroimidazo[1,2-a]pyrimidin-1(5H)-yl)-3-ethylbenzonitrile Trifluoroacetic Acid Salt
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References
1. Tarhan AK, et al. J Med Chem. 2026 Oct 22;69(20):23428-23448.
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