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Chemical Structure : IJ-5
CAS No.: 68776-47-6
Catalog No.: PC-60355Not For Human Use, Lab Use Only.
A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $248 | In stock | |
| 5 mg | $458 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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IJ-5 (1beta-Hydroxyalantolactone) is a potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
IJ-5 shows weak affinity for Ubc13 (Kd=13.37 uM); inhibits TNFα-induced NF-kB pathway activation and inflammatory gene expression in 293T cells.
IJ-5 exhibites potent anti-inflammatory activity against TNF-α- and D-galactosamine-induced hepatitis and collagen-induced arthritis in preclinical models.
| M.Wt | 248.322 | |
| Formula | C15H20O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3aS,5R,8S,8aS,9aS)-8-hydroxy-5,8a-dimethyl-3-methylene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one |
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1. Liu L, et al. Chem Biol. 2014 Oct 23;21(10):1341-50.
2. Chen H, et al. J Med Chem. 2017 Jul 11. doi: 10.1021/acs.jmedchem.6b01829.
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