Chemical Structure : IMB-9C
CAS No.:
1019101-90-6
IMB-9C
Catalog No.: PC-25870Not For Human Use, Lab Use Only.
IMB-9C is a specific small molecule inhibitor of heptad repeat 1/heptad repeat 2 (HR1/HR2) interaction, inhibits SARS-CoV-2-S-mediated cell-cell fusion.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IMB-9C is a specific small molecule inhibitor of heptad repeat 1/heptad repeat 2 (HR1/HR2) interaction, inhibits SARS-CoV-2-S-mediated cell-cell fusion.
IMB-9C exhibits a dose-dependent inhibitory effect on viral entry with EC50 of 32.15 uM.
IMB-9C demonstratesenhanced potency against Omicron variants compared with WT and previous variants.
IMB-9C inhibits virus-induced CPE for WT, Beta, Delta, Ba.1, Ba.2, Ba.4 and Ba.5, with IC50 values of 0.4 -3.1 uM, with low toxicity on mammalian cells such as HEK-293T, Huh-7 and Vero cells.
IMB-9C is able to block 6-HB formation between HR1 and HR2, binds with both HR1 and HR2 with SPR KD of 0.567 uM and 36.8 uM respectively.
Physicochemical Properties
|
M.Wt
|
444.45
|
|
Formula
|
C23H20N6O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-phenylpyrimidin-1(6H)-yl)-N-(3-nitrophenyl)acetamide
|
References
1. Patent CN120037235 A 2025-05-27.
2. Zhang J, et al. Acta Pharm Sin B. 2025 Sep;15(9):4829-4843.
Contact Us
sales@probechem.com
