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IMMH-010

Chemical Structure : IMMH-010

CAS No.: 2158336-02-6

IMMH-010 (IMMH010, YPD-30)

Catalog No.: PC-20281Not For Human Use, Lab Use Only.

IMMH-010 (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IMMH-010 (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.
    YPD-30 is an orally bioavailable prodrug for YPD-29B with significantly higher bioavailability than YPD-29B.
    YPD-30 exhibits antitumor activity by inhibiting PD-L1 in vivo, significantly increased T cell infiltration by increasing CD3 and CD8 expression in hPD-L1 MC38 xenograft tumor tissue, markedly decreased hPD-L1 expression.

    Physicochemical Properties

    M.Wt 639.97
    Formula C32H32BrClN2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    isopropyl (4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-(pyridin-3-ylmethoxy)benzyl)-L-serinate

    References

    1. Fangfang Lai, et al. Acta Pharm Sin B. 2022 Jun;12(6):2845-2858.

    2. Wang Y, et al. Pharmaceutics. 2021 Apr 21;13(5):598.

    3. Patent: CN109153670.

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