Chemical Structure : IMP-2380
CAS No.:
3088774-28-8
IMP-2380
(IMP2380)
Catalog No.: PC-25364Not For Human Use, Lab Use Only.
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay.
IMP-2380 caused a similar fold-decrease in ciprofloxacin MIC as for 1, but at ca. 10-fold lower concentration.
IMP-2380 showed no mammalian cytotoxicity and no antibacterial activity in the absence of ciprofloxacin.
IMP-2380 also potentiated ciprofloxacin activity in MRSA and MSSA clinical isolates.
IMP-2380 binds the outward-open state of NorA
IMP-2380 prevents induction of the ciprofloxacin-induced SOS response.
IMP-2380 (30 mg/kg i.p.) demonstrate robust potentiation with ciprofloxacin in murine infection model of MRSA.
Physicochemical Properties
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M.Wt
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409.89
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Formula
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C21H16ClN3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(benzo[d]thiazol-2-yl)-4-(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)but-3-enoic acid
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References
1. Gray JL, et al. bioRxiv [Preprint]. 2025 Aug 22:2025.08.19.671038.
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