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Chemical Structure : IMR-1
CAS No.: 310456-65-6
Catalog No.: PC-42154Not For Human Use, Lab Use Only.
A small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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IMR-1 is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
IMR-1 non-covalently binds to intracellular domain of Notch (NICD) with Kd of 11 uM, inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines。
IMR-1 dramatically inhibits tumor growth in a patient-derived tumor xenograft model.
| M.Wt | 353.4133 | |
| Formula | C15H15NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester |
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1. Astudillo L, et al. Cancer Res. 2016 Jun 15;76(12):3593-603.
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