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Chemical Structure : IMU-935
Catalog No.: PC-20040Not For Human Use, Lab Use Only.
IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.
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IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM.
MU-935 is shown to be a DHODH Inhibitor with an IC50 of 240 nM.
IMU-935 demonstrates synergistic inhibition of the secretion of IL-17A, IL-17F and IFNγ with IC50 concentrations of 3-5 nM tested in stimulated human lymphocytes.
IMU-935 inhibits Th17 differentiation of murine cells (IC50=135 nM), and inhibits IL-17F production from stimulated human PBMCs with IC50 of 2-4 nM.
IMU-935 demonstrates a strong inhibition of GM-CSF, IL-17A, IL-17F and IL-22 in inflamed human skin model (skin punches from human healthy volunteers).
IMU-935 does not affect thymocyte development.
| M.Wt | 495.86 | |
| Formula | C22H18ClF4N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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