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Chemical Structure : IN-1130
Catalog No.: PC-70054Not For Human Use, Lab Use Only.
A potent ALK5 inhibitor.
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A potent ALK5 inhibitor; inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM; highly selective in a panel of 27 serine/threonine and tyrosine kinases including p38α; decreases levels of TGF-beta1 mRNA, type I collagen mRNA, and pSmad2, compared to UUO control rats; inhibits renal fibrosis in obstructive nephropathy in vivo models.
| M.Wt | 420.47 | |
| Formula | C25H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moon JA, et al. Kidney Int. 2006 Oct;70(7):1234-43.
2. Ryu JK, et al. J Sex Med. 2009 May;6(5):1284-96.
3. Park CY, et al. Cancer Lett. 2014 Aug 28;351(1):72-80.
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