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Chemical Structure : INCB040093
Catalog No.: PC-60176Not For Human Use, Lab Use Only.
Dezapelisib (INCB040093) is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM.
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Dezapelisib (INCB040093) is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM.
Dezapelisib (INCB040093) displays 74 to >900-fold selectivity for the other PI3K family members, and does not inhibit a panel of 57 additional kinases.
Dezapelisib (INCB040093) potently inhibits cellular proliferation CD19+ human or CD21+ canine primary B cells with IC50 of 1-3 nM, reduces anti-FcR-induced basophil activation in the presence of human whole blood (IC50=33 nM).
Dezapelisib (INCB040093) demonstrates promising efficacy in patients with Hodgkin's lymphoma in clinical studies.
| M.Wt | 421.454 | |
| Formula | C20H16FN7OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shin N, et al. J Pharmacol Exp Ther. 2017 Nov 10. pii: jpet.117.244947.
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