INCB081776 | AXL/MER inhibitor | Probechem Biochemicals

Chemical Structure : INCB081776

Catalog No.: PC-20332Not For Human Use, Lab Use Only.

INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3.

M.Wt	635.73
Formula	C34H37N9O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide

1. Rios-Doria J, et al. Front Oncol. 2020 Dec 7;10:598477.