Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : INCB9471
Catalog No.: PC-60672Not For Human Use, Lab Use Only.
INCB9471 is a potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
INCB9471 is a potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs.
INCB9471 inhibits CCR5-mediated signaling events such as intracellular calcium mobilization, ERK phosphorylation, and CCR5 receptor internalization with IC50 values of 16, 3, and 1.5 nM, respectively.
INCB9471 demonstrates anti-HIV-1 activity against R5 HIV-1 strains representing the major clades including A, B, C, D, E, F, G, and J with mean IC50 of 9 nM in PBMCs.
INCB9471 also is a potent inhibitor of mutant HIV-1 variants that are resistant to other drugs including NRTIs, NNRTIs, PIs, and the fusion inhibitor T20.
| M.Wt | 559.678 | |
| Formula | C30H40F3N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xue CB, et al. ACS Med Chem Lett. 2010 Aug 25;1(9):483-7.
2. Shin N, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
