Catalog No.: PC-27088Not For Human Use, Lab Use Only.
INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses.
INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses.
INI3069 induce STING- and IRF3-dependent but ATG5-independent antiviral activity.
INI3069 suppressed CHIKV in THF-MAVS/TRIF−/− (IC50=0.6758 μM) and THF-ATG5−/− cells (IC50 = 0.5171 μM).
INI3069 elicits phosphorylation of TBK1 that was enhanced in STING+/+ and measurable in STING−/− cells.
INI3069 does not bind to the STING cytosolic domain and requires an intact TMD oligomerization domain for activation.
INI3069 blocks agonist-mediated Golgi trafficking and STING-mediated autophagy.
INI3069 blocks STING-mediated TFEB dephosphorylation and autophagy.
INI3069 enhances both humoral responses to co-administered antigen and anti-tumor responses.
INI3069 induces different molecular and immune effects compared to conventional STING agonists.
