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Chemical Structure : INO-1001
CAS No.: 501364-82-5
Catalog No.: PC-42837Not For Human Use, Lab Use Only.
INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP).
INO-1001 significantly radiosensitizes human and rodent cell lines at 10 uM (enhancement ratios 1.4-1.6), enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death.
INO-1001 attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury.
| M.Wt | 439.53 | |
| Formula | C23H25N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3-Morpholinopropyl)-5-oxo-6,11-dihydro-5H-indeno[1,2-c]isoquinoline-9-sulfonamide |
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1. Shimoda K, et al. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L240-9.
2. Szabó G, et al. Shock. 2004 May;21(5):426-32.
3. Du X, et al. J Clin Invest. 2003 Oct;112(7):1049-57.
4. Brock WA, et al. Cancer Lett. 2004 Mar 18;205(2):155-60.
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