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Chemical Structure : INT-777
CAS No.: 1199796-29-6
Catalog No.: PC-20450Not For Human Use, Lab Use Only.
INT-777 (S-EMCA) is a potent, selective TGR5 agonist with EC50 of 0.82 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $188 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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INT-777 (S-EMCA) is a potent, selective TGR5 agonist with EC50 of 0.82 uM.
INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner.
INT-777 induces GLP-1 release in enteroendocrine cells.
INT-777 (30 mg/kg, oral) stimulates the secretion of glucagon-like peptide 1 (GLP-1) in mice after a glucose challenge.
INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity.
INT-777 also stimulates insulin secretion in pancreatic β-cells, reduces inflammation and inhibits atherosclerosis in mice.
| M.Wt | 450.66 | |
| Formula | C27H46O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-4-((3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylpentanoic acid |
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1. Pellicciari R, et al. J Med Chem. 2009 Dec 24;52(24):7958-61.
2. Pruzanski M, et al. Cell Metab. 2009 Sep;10(3):167-77.
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