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IOX2

Chemical Structure : IOX2

CAS No.: 931398-72-0

IOX2 (PHD2 inhibitor, IOX-2)

Catalog No.: PC-28710Not For Human Use, Lab Use Only.

IOX2 is a hypoxia-mimicking compound and specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM, promotes articular chondrocyte differentiation, regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production.

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Biological Activity

IOX2 is a hypoxia-mimicking compound and specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM, promotes articular chondrocyte differentiation, regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production.

Physicochemical Properties

M.Wt 352.35
Formula C19H16N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

References

1. Sen A, et al. PLoS One. 2013 Nov 11;8(11):e78684.

2. Cheng S, et al. Sci Rep. 2017 Mar 28;7:45408.

3. Deppe J, et al. Arch Toxicol. 2016 May;90(5):1141-50.

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