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Chemical Structure : IOX4
CAS No.: 1154097-71-8
Catalog No.: PC-35269Not For Human Use, Lab Use Only.
IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $188 | In stock | |
| 100 mg | $388 | In stock | |
| 500 mg | Get quote |
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IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases; inhibits prolyl hydroxylation and increases HIF-1α levels in cells (IC50=5.6 to 11.7 µM), also induces HIF-1α and HIF-2α expression in mice.
| M.Wt | 328.3 | |
| Formula | C15H16N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1-dimethylethyl ester 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-3-pyridinecarboxylic acid |
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1. Chan MC, et al. PLoS One. 2015 Jul 6;10(7):e0132004.
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