Chemical Structure : IP6C
CAS No.:
103313-38-8
IP6C
Catalog No.: PC-24460Not For Human Use, Lab Use Only.
IP6C is a small molecule inhibitor of type II Thoeris systems encoded by multiple bacteria species, inhibits BaY2 Thoeris with IC50 of 10 uM, inhibits the type II Thoeris system by blocking His-ADPR production by ThsB.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IP6C is a small molecule inhibitor of type II Thoeris systems encoded by multiple bacteria species, inhibits BaY2 Thoeris with IC50 of 10 uM, inhibits the type II Thoeris system by blocking His-ADPR production by ThsB.
IP6C blocks production of the His-ADPR alarm signal.
IP6C also promotes the reproduction of SPO1 on B. subtilis cells expressing BaY2 Thoeris.
IP6C indirectly inhibit ThsA activation by competitively inhibiting His-ADPR production by ThsB.
IP6C inhibits type II Thoeris systems of antibiotic-resistant pathogens.
IP6C improves the survival rate of mice undergoing phage therapy against phage-resistant P. aeruginosa containing the type II Thoeris system.
Physicochemical Properties
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M.Wt
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161.16
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Formula
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C8H7N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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imidazo[1,2-a]pyridine-6-carboxamide
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References
1. Zang Z, et al. bioRxiv [Preprint]. 2025 Feb 21:2025.02.20.638879.
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