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Chemical Structure : IPAG
CAS No.: 193527-91-2
Catalog No.: PC-60076Not For Human Use, Lab Use Only.
IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
IPAG induces autophagic degradation of PD-L1 in PC3 and MDA-MB-231 cells.
| M.Wt | 395.29 | |
| Formula | C17H22IN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
50 mM in ethanol;100 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-Iodophenyl)-3-(2-adamantyl)guanidine |
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1. Wilson AA, et al. J Med Chem. 1991 Jun;34(6):1867-70.
2. Whittemore ER, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):326-38.
3. Schrock JM, et al. Mol Pharmacol. 2013 Nov;84(5):751-62.
4. Maher CM, et al. Mol Cancer Res. 2017 Nov 8. pii: molcanres.0166.2017.
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