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Chemical Structure : IPI-9119
CAS No.: 1346564-56-4
Catalog No.: PC-35893Not For Human Use, Lab Use Only.
IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.
IPI-9119 inhibits PCa cell growth and induces cell cycle arrest and apoptosis, induces a profound metabolic reprogramming in PCa cells.
IPI-9119 also inhibits AR-FL and AR-V7 protein expression and induces ER stress response and protein translation inhibition, inhibits AR transcriptional activity and enhances enzalutamide efficacy in CRPC cells.
IPI-9119 inhibits tumor growth of CRPC xenografts and human mCRPC-derived organoids.
| M.Wt | 495.443 | |
| Formula | C24H19F2N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-(2,6-difluorophenyl)-N-isopropyl-5-oxo-4,5-dihydro-1H-tetrazole-1-carboxamido)-3-phenoxybenzoic acid |
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1. Zadra G, et al. Proc Natl Acad Sci U S A. 2018 Dec 21. pii: 201808834. doi: 10.1073/pnas.1808834116.
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