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Chemical Structure : IPR-179
Catalog No.: PC-72035Not For Human Use, Lab Use Only.
IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively.
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IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively.
IPR-179 dispalys high selectivity over MMP1/3/7/8, ADAM10/17, Prolyl oligopeptidase and DPP4 (IC50=3.3 uM->20 uM).
IPR-179 reduced seizure severity in the rapid-kindling rat model.
IPR-179 reduced the number of spontaneous seizures in the kainic acid model (during and up to 7 weeks after delivery) without side effects while improving cognitive behavior.
IPR-179 prevented an MMP2/9-dependent switch-off normally restraining network excitability during the activity period.
| M.Wt | 631.67 | |
| Formula | C29H41F4N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Diede Wm Broekaart, et al. J Clin Invest. 2021 Jan 4;131(1):e138332.
2. Alexandra Bertran, et al. Bioorg Chem. 2020 Jan;94:103365.
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