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IQDMA

Chemical Structure : IQDMA

CAS No.: 401463-02-3

IQDMA (STAT5 inhibitor IQDMA)

Catalog No.: PC-61312Not For Human Use, Lab Use Only.

IQDMA is a cell-permeable, small molecule inhibitor of the transcription factor STAT5, and dual STAT3/5 degrader (IC50=0.54-1.63 μM).

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    Biological Activity

    IQDMA is a cell-permeable, small molecule inhibitor of the transcription factor STAT5, and dual STAT3/5 degrader (IC50=0.54-1.63 μM).
    IQDMA exhibits anticancer activity and inhibits the growth of A549, HL-60 and K562 cells with IC50 of 8, 5 and 8 uM, respectively.
    IQDMA is a broad‐range multi‐kinase inhibitor that suppresses STAT3/5 nuclear levels.
    IQDMA and PAK kinase inhibitor FRAx597 are highly effective in reducing tumor growth in an intradermal xenograft mouse model.

    Physicochemical Properties

    M.Wt 304.397
    Formula C19H20N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N'-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine

    References

    1. Hu XW, et al. Cell Biol Toxicol. 2006 Nov;22(6):417-27.

    2. Chien CM, et al. Chem Biol Interact. 2008 Oct 22;176(1):40-7.

    3. Hodge LS, et al. Blood. 2014 Feb 13;123(7):1055-8.

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