Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : IQS-019
Catalog No.: PC-60403Not For Human Use, Lab Use Only.
IQS-019 is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
IQS-019 is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.
IQS-019 inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs.
IQS-019 impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib.
| M.Wt | 510.423 | |
| Formula | C25H25Cl2N7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80.
2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
