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Chemical Structure : IQS-019 mesylate
Catalog No.: PC-60404Not For Human Use, Lab Use Only.
A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.
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A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively; inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs; impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib.
| M.Wt | 606.523 | |
| Formula | C26H29Cl2N7O4S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80.
2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75.
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