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Chemical Structure : IRAK4-IN-16
Catalog No.: PC-60980Not For Human Use, Lab Use Only.
A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively.
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A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties.
| M.Wt | 478.519 | |
| Formula | C27H25F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50.
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