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Chemical Structure : IRAK4 inhibitor 23
Catalog No.: PC-61623Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM.
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A potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM; inhibits R848 (TLR7 agonist) stimulated cytokine release in hPBMC with IC50 of 300 nM; exhibits excellent pharmacokinetic profile and kinase selectivity (99%); demonstrates activity in vivo via oral dosing in TLR7 driven model of inflammation.
| M.Wt | 337.427 | |
| Formula | C19H23N5O | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Smith GF, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
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