Catalog No.: PC-61359Not For Human Use, Lab Use Only.
IRES-C11 is a spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells.
IRES-C11 is a spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells.
IRES-C11 shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation.
IRES-C11 significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib.
IRES-C11 shows synergistic anti-MM cytotoxicity combined with ER stress inducers.
IRES-C11 also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.
