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Chemical Structure : IRES-J007
CAS No.: 155514-72-0
Catalog No.: PC-61358Not For Human Use, Lab Use Only.
IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).
IRES-J007 significantly reduces tumor growth of GBM xenografts in mice.
IRES-J007 markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
| M.Wt | 297.31 | |
| Formula | C17H15NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((2,4-Dimethoxyphenyl)methyl)isoindoline-1,3-dione |
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1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59.
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