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Chemical Structure : IRL1620
CAS No.: 142569-99-1
Catalog No.: PC-20103Not For Human Use, Lab Use Only.
IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist for endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | $1280 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist of endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM).
IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats.
IRL-1620 shows neuroprotective effect in rat brain ischemia model, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function.
IRL-1620 also promotes neural progenitor cell differentiation and maturation in vitro and in vivo.
| M.Wt | 1820 | |
| Formula | C86H117N17O27 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21) |
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1. Yukimura T, et al. Eur J Pharmacol. 1994 Nov 3;264(3):399-405.
2. Kobari M, et al. Neurosci Lett. 1994 Aug 1;176(2):157-60.
3. Ranjan, et al. Sci.Rep. 2020. 10 12737.
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