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Chemical Structure : IS811
Catalog No.: PC-73259Not For Human Use, Lab Use Only.
IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.
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IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.
IS811 displays >100-fold selectivity over 5-HT2a, DAT and NET.
IS811 (0-20 mg/kg) dose-dependently inhibited eotaxin-induced eosinophil influx to the lung in vivo.
| M.Wt | 453.602 | |
| Formula | C27H36FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Paul S Watson, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5695-9.
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