Chemical Structure : ISAM-CG557
CAS No.:
ISAM-CG557
Catalog No.: PC-25356Not For Human Use, Lab Use Only.
ISAM-CG557 is a potent, selective, and functionally biased CB2 receptor (CB2R) agonist with binding Ki of 54.6 nM, with negligible binding to CB1R, shows strongly biased toward MAPK signaling.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ISAM-CG557 is a potent, selective, and functionally biased CB2 receptor (CB2R) agonist with binding Ki of 54.6 nM, with negligible binding to CB1R, shows strongly biased toward MAPK signaling.
ISAM-CG557 display notable bias toward MAPK, especially in β-arrestin-MAPK signaling, indicating a selective MAPK pathway activation.
ISAM-CG557 shows EC50 of 0.60 nM and Emax = 60% for CB2R activity.
ISAM-CG557 significantly reduced the production of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) in unstimulated monocytes and macrophages.
ISAM-CG557 elicites a concentration-dependent neuroprotective effect on neurite length in transfected SH-SY5Y cells.
Physicochemical Properties
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M.Wt
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380.42
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Formula
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C21H21FN4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(1-(4-fluorobenzyl)-1H-indazole-3-carbonyl)piperidine-2-carboxamide
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References
1. Gioé-Gallo C, et al. J Med Chem. 2025 Aug 12. doi: 10.1021/acs.jmedchem.5c00604.
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